Bioequivalence of inhaled medications [comment]

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منابع مشابه

Bioequivalence of inhaled drugs.

Correspondence: E. Derom, Dept of Respiratory Diseases, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium. It is generally accepted that inhalation therapy is the most effective way to treat patients with asthma or chronic obstructive pulmonary disease (COPD). Indeed, inhalation of relatively small doses of drug not only results in high, local concentrations in the airways the site of...

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Scientific Rationale for Determining the Bioequivalence of Inhaled Drugs.

In recent years, pathways for the development and approval of bioequivalent inhaled products have been established for regulated markets, including the European Union (EU), and a number of orally inhaled products (OIPs) have been approved in the EU solely on the basis of in vitro and pharmacokinetic data. This review describes how these development pathways are structured and their implications...

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Bioequivalence and Dose Proportionality of Inhaled Fluticasone Furoate

Abbreviations: AE: Adverse Event; AUC(0-t’): Area Under the Curve from Zero (Pre-Dose) to the Time of Last Common Measurable Time Point Within Subject; BLQ: Below the Limit of Quantitation; CI: Confidence Interval; Cmax: Maximum Plasma Concentration; COPD: Chronic Obstructive Pulmonary Disease; CV: Coefficient of Variation; DPI: Dry Powder Inhaler; FF: Fluticasone Furoate; FP: Fluticasone Propi...

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 1992

ISSN: 0306-5251

DOI: 10.1111/j.1365-2125.1992.tb05635.x